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However, the BHMT reaction is limited to the human liver and kidney since BHMT is expressed primarily in the hepatocytes and kidney cortex (Sunden et al., 1997)

2017;171:358e371359

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8 Creatine does raise serum creatinine, a kidney function marker, but this reflects altered creatine metabolism rather than actual renal stress

Other research has also concentrated on developing ionizable lipids or optimizing the lipid formulation in LNP to enhance the delivery of Cas9 mRNA and sgRNA, thereby improving the efficiency of genome editing [146]